health
Alerta médica: mutación mitocondrial poco frecuente impacta seguridad anestésica en niños
La Sociedad Venezolana de Anestesiología (SVA) emitió un comunicado detallando la situación de una variante genética mitocondrial que, aunque extremadamente infrecuente, puede generar complicaciones graves durante procedimientos quirúrgicos con anestesia inhalatoria en pacientes pediátricos.
TL;DR
- A rare mitochondrial genetic variant, mtND4 m.11232T>C, is linked to severe complications in pediatric patients receiving inhalation anesthesia.
- The variant causes energy collapse in high-consumption cells like neurons when exposed to sevoflurane, a common anesthetic.
- Propofol has shown no harmful effects on cells with this mutation.
- The prevalence of this variant appears higher in Venezuela's Carabobo state.
- The SVA is recommending genetic screening, a National Registry for Delayed Awakening, and specific anesthetic protocols (TIVA) for at-risk patients.
- International collaboration and scientific vigilance are underway to understand and manage this rare phenomenon.